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A Beginners Guide to Polynucleotide Treatment

Polynucleotides (PNs) have emerged as a cutting-edge innovation in the field of skincare and aesthetic treatments. These molecules, derived from DNA, have the remarkable ability to stimulate collagen production and improve skin texture. And so, PNs has become a go-to choice for beauty enthusiasts looking for the elixir to a youthful and radiant complexion.

PNs have been gaining popularity in the west in recent years. However, these wonder molecules have been used for a decade in South Korea and China. And so, Polynucleotide treatment has earned a reputation for its effectiveness and safety, making it a staple in the skincare routines of countless individuals across Asia.

What are the differences between Polynucleotides and other dermal filler based skin boosters?

Both PNs and dermal filler based skin boosters are used to improve skin quality and address various signs of aging, but they work through different mechanisms and provide different results.

Different Composition and Mechanism of Action:

Polynucleotide treatment use DNA molecules to stimulate the body to produce more collagen and promote skin rejuvenation at a cellular level. PNs work by enhancing the skin's natural regenerative processes and improving its texture and elasticity.

Dermal filler-based skin boosters typically use hyaluronic acid (HA) to give immediate hydration and volume to the skin. HA skin boosters work by adding moisture and filling in fine lines, wrinkles, and areas with volume loss.

Different Treatment Purposes:

PN treatments are primarily used to improve overall skin quality, including texture, elasticity, and hydration. They can help with fine lines, wrinkles, and dull skin by stimulating collagen synthesis.

Skin booster treatments are primarily aimed at addressing dehydration and restoring a plump and youthful appearance to the skin. They are often used to target specific areas with volume loss, such as the face, neck, or hands.

Where can Polynucleotides be used?

Face, Neck, Decollaté, Body

are areas which PNs can be used to improve skin texture, reduce fine lines and wrinkles, enhance elasticity, and promote an overall youthful appearance. The neck area is prone to signs of aging, such as sagging skin and wrinkles. PN treatments can help tighten and rejuvenate the neck skin. The chest area is also prone to sun damage and therefore, can show aged skin. PN treatments can be used to reduce fine lines and improve skin texture in the décolletage.


concerns like under-eye wrinkles, dark circles, and puffiness can be treated using PNs and improve the overall appearance of the eye area.


from surgery or acne scars can improve by using PNs to promote collagen production and skin regeneration.

What are the benefits of Polynucleotides?

Firming & Tightening

PNs stimulate collagen production, leading to increased skin firmness and elasticity. As collagen levels rise, the skin regains its youthful tautness, reducing the appearance of sagging and fine lines.


: PNs enhance skin brightness by promoting cellular turnover and reducing the effects of sun damage and pigmentation irregularities. This results in a more radiant and even complexion.


: PNs treatments work to smooth the skin's texture, minimising the appearance of roughness, acne scars, and fine wrinkles. This trifecta of benefits makes polynucleotides a sought-after solution for individuals looking to rejuvenate their skin, achieve a more youthful appearance, and enjoy the confidence that comes with healthier, glowing skin.

How do Polynucleotides work to rejuvenate the skin?

PNs work by stimulating collagen production and promoting cellular regeneration in the skin. They increase skin hydration, improve elasticity, and reduce inflammation. This multifaceted approach leads to enhanced skin quality, including increased firmness, reduced wrinkles, improved texture, and a more youthful appearance. PNs may also provide protection against environmental damage and help even out skin tone.

How long does Polynucleotides treatment take to perform?

The duration of a PN treatment session can vary depending on several factors, including the type of PN treatment, the treatment area, and the specific technique used by the clinician. Generally, PN treatments are known for being relatively quick and convenient, making them suitable for individuals with busy schedules.

How long does Polynucleotides results last?

Generally, the longevity of PN results falls within a range of several months to over a year. It's important to note that PN treatments are typically not permanent. To maintain the improvements in skin quality and collagen production, individuals often need to undergo follow-up treatments as recommended by their clinician.

How long does Polynucleotides take to work?

Usually the full effects often become more noticeable over a period of several weeks to a few months as collagen production is stimulated. Some individuals reporting visible improvements in skin texture and hydration within a few days to a week after the initial treatment.

Downtime, Safety & Risks

Although uncommon, some individuals may have allergies or sensitivities to the components used in polynucleotide-based products. It's essential to undergo a patch test or consult with a dermatologist before undergoing treatment to rule out any adverse reactions.

After treatment, there may be mild, temporary side effects at the injection site, such as redness, swelling, bruising, or discomfort. These usually resolve within a few days.

However, with its impressive results and minimal downtime, PNs skincare treatments are quickly gaining traction in London as a sought-after option for those looking to reverse the appearance of aging skin.


  1. Avoid Sun Exposure: Protect your skin from direct sunlight for at least a week following the treatment. UV rays can cause skin sensitivity and increase the risk of hyperpigmentation. If you must go outside, wear a wide-brimmed hat and use a broad-spectrum sunscreen with SPF 30 or higher.
  2. Gentle Cleansing: Use a mild, non-abrasive cleanser to clean your face. Avoid harsh scrubs or exfoliants for a few days after treatment.
  3. Moisturise: Apply a gentle, hydrating moisturiser to keep the skin adequately hydrated. Look for products that are fragrance-free and suitable for sensitive skin.
  4. Avoid Makeup: Refrain from applying makeup or other skincare products for at least 24 hours following the treatment. Your skin needs time to heal and absorb the PN solution.
  5. Minimal Touching: Avoid touching or rubbing the treated area to prevent potential irritation or infection.
  6. Stay Hydrated: Drink plenty of water to help your body flush out toxins and support skin healing.
  7. Avoid Hot Baths and Saunas: For a few days after treatment, avoid hot baths, saunas, and activities that may cause excessive sweating, as they can increase skin sensitivity.
  8. Use Gentle Products: When resuming your regular skincare routine, use gentle products that do not contain harsh chemicals or active ingredients that might irritate the skin.
  9. Follow Post-Treatment Instructions: Your healthcare provider will provide specific post-treatment instructions based on your unique needs. Be sure to follow their recommendations carefully.
  10. Attend Follow-Up Appointments: If your treatment requires multiple sessions, make sure to attend all scheduled follow-up appointments as recommended by your healthcare provider.

Additionally, maintaining a consistent skincare routine and following your clinician's aftercare instructions will contribute to achieving the best possible results from your Polynucleotide treatment.

Last updated
2 March, 2024
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